All fields are required.

Close Appointment form

Drosophila Development Lab

  • Home
  • Drosophila Development Lab

Drosophila Development Lab

LAB

About the DDL

Normal development and maintenance of adult organism homeostasis relies on a regulatory cross talk between tissue morphogenesis, differentiation and cell division, which is crucial for organogenesis and for tissue integrity, growth and renewal. Our main research interest is to take advantage of Drosophila melanogaster as a model system to study tissue morphogenesis and cell division during development. Since tumorigenesis is frequently associated with loss of tissue integrity and misregulation of cell proliferation, we expect this work will give a contribution into a better understanding of molecular and cellular processes associated with the onset and development of cancer. More information can be found here and here.
 

 

Publications (2008-2017)

Pimenta-Marques, A., Tostões, R., Marty, T., Barbosa, V., Lehmann, R., and Martinho R.G. (*) (2008). Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Developmental Biology, Nov 15; 323 (2): 197-206.
(*) Corresponding author.
(JCR 2008 impact factor of DEVELOPMENTAL BIOLOGY is 4.416)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2008)

Rangan P., DeGennaro M., Jaime-Bustamante K. , Coux R., Martinho R.G., and Lehmann R. (2009). Temporal and spatial control of germ plasm RNAs. Current Biology, 19 (1): 72-7.
(JCR 2009 impact factor of CURRENT BIOLOGY is 10.992)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2009)

de las Heras J.M. (*), Martinho R.G. (*), Lehmann R, and Casanova J. (2009). A functional antagonism between pgc and torso in the development of the germ-line and somatic cells. EMBO Reports, Sep; 10 (9): 1059-65.
(*) Authors gave an equal contribution.
(JCR 2009 impact factor of EMBO REPORTS is 6.907)
(Journal of Quartile 1 – category “Genetics” according to SJR year 2009)

Van Damme, P. (*), Hole, K. (*), Pimenta-Marques, A. (*), Helsens, K., Vandekerckhove, J., Martinho, R.G., Gevaert, K., Arnesen, T. (2011). NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation PLoS Genetics, Jul; 7 (7): e1002169.
(*) Authors gave an equal contribution.
(JCR 2011 impact factor of PLOS GENETICS is 8.694)
(Top 5% journal – category “Molecular Biology” according to SJR year 2011)

Guilgur L., Prudêncio P., Ferreira T., Pimenta-Marques A., Martinho, R.G. (*) (2012). Drosophila aPKC is required for mitotic spindle orientation in larval wing discs. Development, Feb; 139 (3): 503-13.
(*) Corresponding author.
(JCR 2012 impact factor of DEVELOPMENT is 6.208)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2012)

Alves E., Henriques B.J., Rodrigues J.V., Prudêncio P., Rocha H., Vilarinho L., Martinho R.G. (*), Gomes C.M. (*) (2012). Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. Biochim Biophys Acta – Molecular Basis of Disease, May 9; 1822 (8): 1284-1292.
(*) Co-corresponding authors.
(JCR 2012 impact factor of BBA-Molecular Basis of Disease is 4.91)
(Journal of Quartile 1 – category “Molecular Biology” according to SJR year 2012)
(This publication was featured on the cover of BBA-Molecular Basis of Disease)

Guilgur L., Prudêncio P., Sobral D., Lisekova D., Martinho R.G.(*). (2014). Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. eLife, Apr 22; 3: e02181.
(*) Corresponding author.
(JCR 2014 impact factor of eLife is 9.322)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2014)

Pereira P.A., Navarro-Costa P., Martinho R.G. and Becker J.D. (2014). Evolutionarily conserved mechanisms of male germline development in flowering plants and animals. Biochemical Society Transactions, Apr; 42 (2): 377-82.
(JCR 2014 impact factor of Biochemical Society Transactions is 3.194)
(Journal of Quartile 1 – category “Biochemistry” according to SJR year 2014)

Ferreira T, Prudêncio P, Martinho R.G. (*) (2014). Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. Developmental Biology, Oct 15; 394 (2): 277-91.
(*) Corresponding author.
(JCR 2014 impact factor of Developmental Biology is 3.547)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2014)
(This publication was featured on the cover of Developmental Biology)

Martinho R.G. (*) , Guilgur L.G., Prudêncio P. (2015). How gene expression in fast-proliferating cells keeps pace. Bioessays, May; 37 (5): 514-24.
(*) Corresponding author.
(JCR 2015/2016 impact factor of BioEssays is 4.725)
(Journal of Quartile 1 – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2015)

Silva R. and Martinho R.G. (*) (2015). Developmental roles of Protein N-terminal acetylation. Proteomics, Jul; 15 (14): 2402-9.
(*) corresponding author.
(JCR 2015/2016 impact factor of Proteomics is 4.079)
(Journal of Quartile 1 – category “Biochemistry” according to SJR year 2015)

Rathore OS., Faustino A., Prudêncio P., Van Damme P., Cox C.J., Martinho R.G. (*) (2016). Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Scientific Reports, Feb 10; 6: 21304.
(*) Corresponding author.
(JCR 2016/2017 impact factor of Scientific Reports is 4.259)
(Journal of Quartile 1 – category “Multidisciplinary” according to SJR year 2016)

Navarro-Costa P., McCarthy A., Prudêncio P., Guilgur L.G., Becker J.D., Rangan P. (*) and Martinho R.G. (*) (2016). Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin architecture. Nature Communications, Aug 10; 7: 12331
(*) Co-Corresponding authors.
(JCR 2016/2017 impact factor of Nature Communications is 12.124)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2016)

Ribeiro AL, Silva RD, Foyn H, Tiago MN, Rathore OS, Arnesen T, Martinho R.G. (*) (2016). Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion. Scientific Reports, Dec 20; 6: 39118.
(*) Corresponding author.
(JCR 2016/2017 impact factor of Scientific Reports is 4.259)
(Journal of Quartile 1 – category “Multidisciplinary” according to SJR year 2016)

Rui D Silva, Mihailo Mirkovic, Leonardo G Guilgur, Om S. Rathore, Rui Goncalo Martinho (*), Raquel A Oliveira (*) (2018). Absence of the Spindle Assembly Checkpoint restores mitotic fidelity upon loss of sister chromatid cohesion. Current Biology 2018 Sep 10;28(17):2837-2844.e3. doi: 10.1016/j.cub.2018.06.062.
(*) Co-corresponding authors
(JCR 2016/2017 impact factor of Current Biology is 8.851)

Pedro Prudêncio, Leonardo G. Guilgur, João Sobral, Jörg D. Becker, Rui Gonçalo Martinho (*), Paulo Navarro-Costa (*) (2018). The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization. EMBO Reports 2018 Aug;19(8). pii: e45728. doi: 10.15252/embr.201845728.
(*) Co-corresponding authors
(JCR 2016/2017 impact factor of EMBO Reports is 8.568)

Project Grants

FCT I&D Project: PTDC/BBB-BQB/0712/2012 (2013-2015). Principal investigator: Rui Gonçalo Martinho. Title: “Protein targeting and N-terminal acetylation”.
Funding: 194.664 euros.

FCT I&D Project: PTDC/BEX-BID/0395/2014 (2016-2019). (Ongoing Project). Principal Investigator: Rui Gonçalo Martinho. Title: “Molecular constraints to pre-mRNA splicing in fast dividing cells.”.
Funding: 198.831 euros.

FCT I&D Project: PTDC/BIA-BID/28441/2017 (2018-2021) (Ongoing Project). Principal Investigator: Rui Gonçalo Martinho. Title: “Awakening of the oocyte: transcriptional reactivation after prolonged quiescence.”
Funding: 239.995 euros

 

Patents

US patent (published), US9416391 B2, “Method for identifying cancer drug candidates in Drosophila”, publication date: 16th August 2016; authors: Rui Goncalo Martinho , Virginia Mylena Oliveira Marques, and Richard John Hampson.

 

Team

 

Representative Images